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The antibody against PPCS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-311 of human PPCS (NP_078940.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PPCS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-311 of human PPCS (NP_078940.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03278A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PPCS |
| Target Synonyms | CMD2C; PPCS | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, 293T, HepG2, Mouse brain, OVCAR3, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-311 of human PPCS (NP_078940.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9HAB8 | Immunogen Sequence |
Uniprot Id
Q9HAB8
Target Species
Human
Target Name
PPCS
Target Full Name
Phosphopantothenate--cysteine ligase
Target Function
Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate.
Target Protein Families
PPC synthetase family
Target Synonyms
COAB; FLJ11838; MGC117357; MGC138220; OTTHUMP00000008433; Phosphopantothenate--cysteine ligase; Phosphopantothenoylcysteine synthetase; PPC synthetase; Ppcs; PPCS_HUMAN; RP11-163G10.1
Target Background
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).
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