Rabbit anti-Human NKX6-1 Polyclonal Antibody

The antibody against NKX6-1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human NKX6-1 (NP_006159.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-04299A

Number

Cat.No	ADA-04299A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	NKX6-1
Target Synonyms	NKX6A; NKX6.1; NKX6-1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	BxPC-3, Rat pancreas	Application	ELISA, WB, IHC-P

Cat.No

ADA-04299A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

NKX6-1

Target Synonyms

NKX6A; NKX6.1; NKX6-1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

BxPC-3, Rat pancreas

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NKX6-1 (NP_006159.2).	Target Species	Human
Immunogen Sequence	MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGIND	Uniprot ID	P78426

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NKX6-1 (NP_006159.2).

Target Species

Human

Immunogen Sequence

MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGIND

Uniprot ID

P78426

Background Information

Uniprot Id

P78426
Target Species

Human
Target Name

NKX6-1
Target Full Name

Homeobox protein Nkx-6.1
Target Function

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.
Target Subcellular Location

Nucleus.
Target Tissue Specificity

Pancreatic beta cells.
Target Synonyms

Homeobox protein NK-6 homolog A; Homeobox protein Nkx-6.1; NK homeo box, family 6, member A ; NK homeobox (Drosophila), family 6, A; NK homeobox, family 6, A ; NK6 homeobox 1; NK6 transcription factor homolog A ; NK6 transcription factor related, locus 1 ; NK6 transcription factor related, locus 1 (Drosophila); NKX6-1; NKX6.1; NKX61; NKX61_HUMAN; NKX6A
Target Background

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].

Rabbit anti-Human NKX6-1 Polyclonal Antibody

Specifications

Immunogen Information

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