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The antibody against HPD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-393 of human HPD (NP_002141.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against HPD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-393 of human HPD (NP_002141.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-10708A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HPD |
| Target Synonyms | PPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE; HPD | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, HL-60, Mouse liver, Rat kidney, Rat liver | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-393 of human HPD (NP_002141.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P32754 | Immunogen Sequence |
Uniprot Id
P32754
Target Species
Human
Target Name
HPD
Target Full Name
4-hydroxyphenylpyruvate dioxygenase
Target Function
Key enzyme in the degradation of tyrosine.
Target Involvement
Tyrosinemia 3 (TYRSN3); Hawkinsinuria (HAWK)
Target Protein Families
4HPPD family
Target Research Area
Metabolism
Target Synonyms
4 HPPD; 4 hydroxyphenylpyruvate dioxygenase; 4 hydroxyphenylpyruvic acid oxidase; 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; GLOD3 ; glyoxalase domain containing 3; HPD; HPPD_HUMAN; HPPDase; PPD
Target Background
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.
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