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The antibody against PAX2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 150-320 of human PAX2 (NP_003978.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against PAX2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 150-320 of human PAX2 (NP_003978.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-11261A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PAX2 |
| Target Synonyms | FSGS7; PAPRS; PAX-2; PAX2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Jurkat, PC-12 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 150-320 of human PAX2 (NP_003978.3). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | TPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVS | Uniprot ID | Q02962 |
Uniprot Id
Q02962
Target Species
Human
Target Name
PAX2
Target Full Name
Paired box protein Pax-2
Target Function
Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS.
Target Involvement
Papillorenal syndrome (PAPRS); Focal segmental glomerulosclerosis 7 (FSGS7)
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.
Target Research Area
Developmental Biology
Target Synonyms
PAX2; Paired box protein Pax-2
Target Background
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
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