Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against PRA1 was raised in rabbit using the Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against PRA1 was raised in rabbit using the Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-02645A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PRA1 |
| Target Synonyms | PRA1 antibody; FBP1 antibody; CAALFM_C406980WA antibody; CaO19.10623 antibody; CaO19.3111 antibody; pH-regulated antigen PRA1 antibody; 58 kDa fibrinogen-binding mannoprotein antibody | Form | Liquid |
| Species Reactivity | Candida albicans | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA) | Target Species | Candida albicans |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P87020 |
Uniprot Id
P87020
Target Species
Candida albicans
Target Name
PRA1
Target Function
Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.
Target Subcellular Location
Secreted. Note=Found primarily on the cell surface of filamentous forms and enriched at hyphal tips.
Target Protein Families
ZPS1 family
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
