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The antibody against notch1a was raised in rabbit using the Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against notch1a was raised in rabbit using the Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-08964A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | notch1a |
| Form | Liquid | Species Reactivity | Zebrafish |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA) | Target Species | Danio rerio (Zebrafish) (Brachydanio rerio) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P46530 |
Uniprot Id
P46530
Target Species
Zebrafish
Target Name
NOTCH1A
Target Function
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.; [Notch 1 intracellular domain]: Nucleus.
Target Protein Families
NOTCH family
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