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The antibody against mcr1 was raised in rabbit using the Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 protein (1-541AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against mcr1 was raised in rabbit using the Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 protein (1-541AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-16151A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | mcr1 |
| Target Synonyms | mcr1; mcr-1; APZ14_31440; Probable phosphatidylethanolamine transferase Mcr-1; Polymyxin resistance protein MCR-1 | Form | Liquid |
| Species Reactivity | Escherichia coli | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 protein (1-541AA) | Target Species | Escherichia coli |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | A0A0R6L508 |
Uniprot Id
A0A0R6L508
Target Species
E.coli
Target Name
MCR1
Target Function
Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance.; Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin.
Target Subcellular Location
Cell inner membrane; Multi-pass membrane protein.
Target Protein Families
Phosphoethanolamine transferase family
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