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The antibody against ABCA3 was raised in rabbit using the Synthetic peptide of human ABCA3 as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
The antibody against ABCA3 was raised in rabbit using the Synthetic peptide of human ABCA3 as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
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Western Blot Positive WB detected in: SY5Y whole cell lysate, MCF7 whole cell lysate, 293 whole cell lysate, PC-3 whole cell lysate All lanes: ABCA3 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 192 kDa Observed band size: 192 kDa
Immunofluorescence staining of MCF-7 cell with ABCA3 Antibody at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).2
Immunofluorescence staining of SH-SY5Y cell with ABCA3 Antibody at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).3
| Cat.No | ADC-00051A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ABCA3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.05% NaN3, 40% Glycerol., Rabbit IgG in pH7.4 PBS |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of human ABCA3 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99758 |
Uniprot Id
Q99758
Target Species
Human
Target Name
ABCA3
Target Full Name
Phospholipid-transporting ATPase ABCA3
Target Function
Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant. Transports preferentially phosphatidylcholine containing short acyl chains. In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity.
Target Involvement
Pulmonary surfactant metabolism dysfunction 3 (SMDP3)
Target Subcellular Location
Endosome, multivesicular body membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Late endosome membrane. Lysosome membrane.
Target Protein Families
ABC transporter superfamily, ABCA family
Target Tissue Specificity
Expressed in brain, pancreas, skeletal muscle and heart. Highly expressed in the lung in an AT2-cell-specific manner. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma.
Target Synonyms
ABC 3; ABC C; ABC C transporter; ABC transporter 3; ABC-C transporter; ABC3; ABCA 3; Abca3; ABCA3 protein; ABCA3_HUMAN; ABCC; ATP binding cassette 3; ATP binding cassette sub family A (ABC1) member 3; ATP binding cassette sub family A member 3; ATP binding cassette transporter 3; ATP-binding cassette 3; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; CED7. C. elegans; homolog of; EST111653; LBM 180; LBM180; MGC72201; P180 Lamellar Body Protein; SMDP3
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