Rabbit anti-Human ACTA2 Polyclonal Antibody

Uniprot Id

P62736

Target Species

Human

Target Name

ACTA2

Target Full Name

Actin, aortic smooth muscle

Target Function

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Target Involvement

Aortic aneurysm, familial thoracic 6 (AAT6); Moyamoya disease 5 (MYMY5); Multisystemic smooth muscle dysfunction syndrome (MSMDYS)

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

Actin family

Target Research Area

Signal Transduction

Target Synonyms

a actin; AAT6; ACTA_HUMAN; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin; aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; alpha sma; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; GIG46; Growth inhibiting gene 46; MYMY5

Target Background

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome.