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The antibody against ADGRA2 was raised in rabbit using the Recombinant Human Adhesion G protein-coupled receptor A2 protein (1069-1338AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against ADGRA2 was raised in rabbit using the Recombinant Human Adhesion G protein-coupled receptor A2 protein (1069-1338AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human liver cancer using ADGRA2 Antibody at dilution of 1:1002
| Cat.No | ADC-08722A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ADGRA2 |
| Form | Liquid | Species Reactivity | Human, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Adhesion G protein-coupled receptor A2 protein (1069-1338AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96PE1 |
Uniprot Id
Q96PE1
Target Species
Human
Target Name
ADGRA2
Target Full Name
Adhesion G protein-coupled receptor A2
Target Function
Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly. Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell projection, filopodium.
Target Protein Families
G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
Target Tissue Specificity
Expressed in endothelial cells (at protein level). Abundantly expressed in heart, placenta, ovary, small intestine, and colon.
Target Synonyms
DKFZp434C211; DKFZp434J0911; FLJ14390; G protein coupled receptor 124; G-protein coupled receptor 124; GP124_HUMAN; GPR 124; Gpr124; KIAA1531; TEM 5; TEM5; Tumor endothelial marker 5; Tumor endothelial marker 5 precursor
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