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The antibody against ADHFE1 was raised in rabbit using the Synthetic peptide of Human ADHFE1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against ADHFE1 was raised in rabbit using the Synthetic peptide of Human ADHFE1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-27859A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ADHFE1 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human ADHFE1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IWW8 |
Uniprot Id
Q8IWW8
Target Species
Human
Target Name
ADHFE1
Target Full Name
Hydroxyacid-oxoacid transhydrogenase, mitochondrial
Target Function
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.
Target Subcellular Location
Mitochondrion.
Target Protein Families
Iron-containing alcohol dehydrogenase family, Hydroxyacid-oxoacid transhydrogenase subfamily
Target Tissue Specificity
Only expressed in adult liver.
Target Synonyms
ADH8; ADHFE 1; ADHFe1; Alcohol dehydrogenase iron-containing protein 1; Alcohol dehydrogenase; iron containing; 1; Fe containing alcohol dehydrogenase; Fe-containing alcohol dehydrogenase; HOT; HOT_HUMAN; Hydroxyacid oxoacid transhydrogenase; mitochondrial; Hydroxyacid-oxoacid transhydrogenase; mitochondrial
Target Background
The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).
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