Rabbit anti-Human AMOT Polyclonal Antibody

The antibody against AMOT was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1000-1084 of human AMOT (NP_001106962.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-07906A

Number

Cat.No	ADA-07906A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	AMOT
Target Synonyms	AMOT; angiomotin	Form	Liquid
Species Reactivity	Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse lung	Application	ELISA, WB

Cat.No

ADA-07906A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

AMOT

Target Synonyms

AMOT; angiomotin

Form

Liquid

Species Reactivity

Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse lung

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1000-1084 of human AMOT (NP_001106962.1).	Target Species	Human
Immunogen Sequence	QTQAPTSAPAVAPTPAPTPTPAVAQAEVPASPATGPGPHRLSIPSLTCNPDKTDGPVFHSNTLERKTPIQILGQEPDAEMVEYLI	Uniprot ID	Q4VCS5

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1000-1084 of human AMOT (NP_001106962.1).

Target Species

Human

Immunogen Sequence

QTQAPTSAPAVAPTPAPTPTPAVAQAEVPASPATGPGPHRLSIPSLTCNPDKTDGPVFHSNTLERKTPIQILGQEPDAEMVEYLI

Uniprot ID

Q4VCS5

Background Information

Uniprot Id

Q4VCS5
Target Species

Human
Target Name

AMOT
Target Full Name

Angiomotin
Target Function

Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Target Subcellular Location

Cell junction, tight junction. Note=Localized on the cell surface. May act as a transmembrane protein.
Target Protein Families

Angiomotin family
Target Tissue Specificity

Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
Target Synonyms

AMOT; AMOT_HUMAN; Angiomotin; Angiomotin p130 isoform; KIAA1071
Target Background

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

Rabbit anti-Human AMOT Polyclonal Antibody

Specifications

Immunogen Information

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