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The antibody against ANKS1B was raised in rabbit using the Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B protein (999-1248AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against ANKS1B was raised in rabbit using the Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B protein (999-1248AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using ANKS1B Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using ANKS1B Antibody at dilution of 1:1002
| Cat.No | ADC-16288A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ANKS1B |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B protein (999-1248AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7Z6G8 |
Uniprot Id
Q7Z6G8
Target Species
Human
Target Name
ANKS1B
Target Full Name
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
Target Function
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Target Subcellular Location
Cytoplasm.; [Isoform 2]: Nucleus.; [Isoform 3]: Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body.; [Isoform 4]: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus.
Target Tissue Specificity
Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain
Target Synonyms
AIDA; AIDA-1; Amyloid-beta protein intracellular domain-associated protein 1; Anks1b; ANKS2; Ankyrin repeat and sterile alpha motif domain containing 1B; Ankyrin repeat and sterile alpha motif domain-containing protein 1B; ANS1B_HUMAN; Cajalin 2; E2A-PBX1-associated protein; EB-1; EB1; MGC26087
Target Background
This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene.
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