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Rabbit anti-Human APCS Polyclonal Antibody

The antibody against APCS was raised in rabbit using the Recombinant Human Serum amyloid P-component protein (20-223AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.

ADC-01727A

The antibody against APCS was raised in rabbit using the Recombinant Human Serum amyloid P-component protein (20-223AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.

$299.00

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Specifications


Cat.No ADC-01727A ClonalityPolyclonal
Host SpeciesRabbitTarget NameAPCS
FormLiquidSpecies ReactivityHuman
IsotypeIgGStorage Buffer0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4
Purification Method>95%, Protein G purifiedConjugateNon-conjugated
ApplicationELISA, IHCStorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Human Serum amyloid P-component protein (20-223AA)Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDP02743
Background Information
  • Uniprot Id

    P02743

  • Target Species

    Human

  • Target Name

    APCS

  • Target Full Name

    Serum amyloid P-component

  • Target Function

    Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

  • Target Involvement

    SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

  • Target Subcellular Location

    Secreted.

  • Target Protein Families

    Pentraxin family

  • Target Tissue Specificity

    Found in serum and urine.

  • Target Research Area

    Cardiovascular

  • Target Synonyms

    9.5S alpha 1 glycoprotein; 9.5S alpha-1-glycoprotein; Amyloid P component serum; APCS; MGC88159; Pentaxin related; Pentraxin 2; PTX 2; PTX2; SAMP_HUMAN; SAP; Serum Amyloid P; Serum amyloid P component; Serum amyloid P-component(1-203)

  • Target Background

    The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

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