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The antibody against ARNT2 was raised in rabbit using the Synthesized peptide derived from internal of Human ARNT2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against ARNT2 was raised in rabbit using the Synthesized peptide derived from internal of Human ARNT2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from Jurkat cells and 293 cells, using ARNT2 antibody.
| Cat.No | ADC-41795A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ARNT2 |
| Target Synonyms | ARNT protein 2 antibody; ARNT2 antibody; ARNT2_HUMAN antibody; Aryl hydrocarbon receptor nuclear translocator 2 antibody; bHLHe1 antibody; Class E basic helix-loop-helix protein 1 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human ARNT2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HBZ2 |
Uniprot Id
Q9HBZ2
Target Species
Human
Target Name
ARNT2
Target Full Name
Aryl hydrocarbon receptor nuclear translocator 2
Target Function
Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE).
Target Involvement
Webb-Dattani syndrome (WEDAS)
Target Subcellular Location
Nucleus.
Target Synonyms
ARNT protein 2; ARNT2; ARNT2_HUMAN; Aryl hydrocarbon receptor nuclear translocator 2; bHLHe1; Class E basic helix-loop-helix protein 1
Target Background
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.
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