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The antibody against ATP8A2 was raised in rabbit using the Recombinant Human Phospholipid-transporting ATPase IB protein (358-570AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against ATP8A2 was raised in rabbit using the Recombinant Human Phospholipid-transporting ATPase IB protein (358-570AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human testis tissue using ATP8A2 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using ATP8A2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-13704A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ATP8A2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Phospholipid-transporting ATPase IB protein (358-570AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NTI2 |
Uniprot Id
Q9NTI2
Target Species
Human
Target Name
ATP8A2
Target Full Name
Phospholipid-transporting ATPase IB
Target Function
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
Target Involvement
Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 4 (CMARQ4)
Target Subcellular Location
Membrane; Multi-pass membrane protein. Golgi apparatus. Endosome. Cell projection, cilium, photoreceptor outer segment. Cell membrane. Photoreceptor inner segment.
Target Protein Families
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Target Tissue Specificity
Strongly expressed in the brain, cerebellum, retina and testis.
Target Synonyms
AT8A2_HUMAN; ATP; Atp8a2; ATPase aminophospholipid transporter class I type 8A member 2; ATPase aminophospholipid transporter like class I type 8A member 2; ATPase class I type 8A member 2; ATPase phospholipid transporting 8A2; ATPIB; CAMRQ4; EC=3.6.3.1; IB; ML-1; ML1; P4 ATPase flippase complex alpha subunit ATP8A2; Probable phospholipid-transporting ATPase IB
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