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Rabbit anti-Human BCAN Polyclonal Antibody

The antibody against BCAN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-00997A

The antibody against BCAN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-00997A ClonalityPolyclonal
Host SpeciesRabbitTarget NameBCAN
Target SynonymsBEHAB; CSPG7; BCANFormLiquid
Species ReactivityHuman, MouseIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.01% thimerosal, pH7.3.Purification MethodAffinity purification
Positive SamplesHeLa, K-562, MCF7, Mouse brain, RajiApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3).Target SpeciesHuman
Immunogen SequenceVPLLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVLRYRCREGLAQRNLPLIRCQENGRWEAPQISCVPRRPARALHPEEDPEGRQGRLLGRWKALLIPPSSPMPGPUniprot IDQ96GW7
Background Information
  • Uniprot Id

    Q96GW7

  • Target Species

    Human

  • Target Name

    BCAN

  • Target Full Name

    Brevican core protein

  • Target Function

    May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

  • Target Subcellular Location

    [Isoform 1]: Secreted, extracellular space, extracellular matrix.; [Isoform 2]: Membrane; Lipid-anchor, GPI-anchor.

  • Target Protein Families

    Aggrecan/versican proteoglycan family

  • Target Tissue Specificity

    Expressed in the retina, specifically in the inner nuclear layer, inner plexiform layer and ganglion cell layer (at protein level).

  • Target Synonyms

    BCAN; BEHAB; CSPG7; UNQ2525/PRO6018; Brevican core protein; Brain-enriched hyaluronan-binding protein; BEHAB; Chondroitin sulfate proteoglycan 7

  • Target Background

    This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants.

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