Rabbit anti-Human BCAT1 Polyclonal Antibody

Uniprot Id

P54687

Target Species

Human

Target Name

BCAT1

Target Full Name

Branched-chain-amino-acid aminotransferase, cytosolic

Target Function

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Class-IV pyridoxal-phosphate-dependent aminotransferase family

Target Tissue Specificity

During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.

Target Synonyms

BCAT ; BCAT(c); Bcat1; BCAT1_HUMAN; BCT1 ; Branched chain amino acid aminotransferase; cytosolic ; branched chain amino-acid transaminase 1; cytosolic; branched chain aminotransferase 1; branched chain aminotransferase 1; cytosolic; Branched-chain-amino-acid aminotransferase; cytosolic; DKFZp686E12175 ; EC 2.6.1.42; ECA39 ; MECA39 ; placental protein 18; PNAS 121 ; PP18; Protein ECA39

Target Background

This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.