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The antibody against BLMH was raised in rabbit using the Recombinant Human Bleomycin hydrolase protein (1-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against BLMH was raised in rabbit using the Recombinant Human Bleomycin hydrolase protein (1-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human colon cancer using BLMH Antibody at dilution of 1:100
| Cat.No | ADC-45213A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BLMH |
| Target Synonyms | BH antibody; Bleomycin hydrolase antibody; BLM hydrolase antibody; BLMH antibody; BLMH_HUMAN antibody; BMH antibody; EC 3.4.22.40 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Bleomycin hydrolase protein (1-300AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13867 |
Uniprot Id
Q13867
Target Species
Human
Target Name
BLMH
Target Full Name
Bleomycin hydrolase
Target Function
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
Target Subcellular Location
Cytoplasm. Cytoplasmic granule.
Target Protein Families
Peptidase C1 family
Target Synonyms
BH; Bleomycin hydrolase; BLM hydrolase; BLMH; BLMH_HUMAN; BMH; EC 3.4.22.40
Target Background
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.
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