Rabbit anti-Human BMP1 Polyclonal Antibody

Uniprot Id

P13497

Target Species

Human

Target Name

BMP1

Target Full Name

Bone morphogenetic protein 1

Target Function

Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation.; Plays an important role in bone repair by acting as a coactivator of BMP7.

Target Involvement

Osteogenesis imperfecta 13 (OI13)

Target Subcellular Location

Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Secreted.; [Isoform BMP1-3]: Secreted.

Target Protein Families

Peptidase M12A family

Target Tissue Specificity

Ubiquitous.

Target Research Area

Developmental Biology

Target Synonyms

BMP 1; BMP-1; BMP1; BMP1_HUMAN; Bone morphogenetic protein 1; Mammalian tolloid protein; mTld; OI13; PCOLC; PCP; PCP2; Procollagen C endopeptidase; Procollagen C proteinase; Procollagen C-proteinase; TLD; Tolloid; Drosophila; homolog of

Target Background

This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.