Rabbit anti-Human CACNA1G Polyclonal Antibody

Uniprot Id

O43497

Target Species

Human

Target Name

CACNA1G

Target Full Name

Voltage-dependent T-type calcium channel subunit alpha-1G

Target Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Target Involvement

Spinocerebellar ataxia 42 (SCA42)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasm.

Target Protein Families

Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1G subfamily

Target Tissue Specificity

Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser exte

Target Synonyms

CACNA1G; KIAA1123Voltage-dependent T-type calcium channel subunit alpha-1G; Cav3.1c; NBR13; Voltage-gated calcium channel subunit alpha Cav3.1