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The antibody against CACNA1S was raised in Rabbit using the recombinant protein of human CACNA1S as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against CACNA1S was raised in Rabbit using the recombinant protein of human CACNA1S as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of mouse skeletal muscle cells using CACNA1S Rabbit pAb at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.
| Cat.No | ADA-08067A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CACNA1S |
| Target Synonyms | MHS5; DHPRM; HOKPP; TTPP1; CMYP18; Cav1.1; HOKPP1; hypoPP; CCHL1A3; CACNL1A3; CACNA1S | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant protein of human CACNA1S. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13698 |
Uniprot Id
Q13698
Target Species
Human
Target Name
CACNA1S
Target Full Name
Voltage-dependent L-type calcium channel subunit alpha-1S
Target Function
Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Target Involvement
Periodic paralysis hypokalemic 1 (HOKPP1); Malignant hyperthermia 5 (MHS5); Thyrotoxic periodic paralysis 1 (TTPP1)
Target Subcellular Location
Cell membrane, sarcolemma, T-tubule; Multi-pass membrane protein.
Target Protein Families
Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1S subfamily
Target Tissue Specificity
Skeletal muscle specific.
Target Synonyms
alpha-1 polypeptide; CAC1S_HUMAN; CACH1; Cach1b; CACN1; CACNA1S; CACNL1A3; Calcium channel; Calcium channel; L type; alpha 1 polypeptide; isoform 3; skeletal; Calcium channel; L type; alpha 1 polypeptide; isoform 3; skeletal muscle; Calcium channel; L type; alpha 1 polypeptide; isoform 3; skeletal muscle; hypokalemic periodic paralysis; Calcium channel; skeletal muscle dihydropyridine sensitive ; alpha 1 subunit; Calcium channel; voltage dependent; L type; alpha 1S subunit; Calcium channel; voltage-dependent; L type; alpha 1S subunit; b; Cav1.1; CCHL1A3; Dihydropyridine receptor; Dihydropyridine sensitive L type calcium channel alpha 1 subunit; fmd; HOKPP; HypoPP; isoform 3; L type; Malignant hyperthermia susceptibility 5; mdg; MHS5; ROB1; sj; skeletal muscle; TTPP1; Voltage gated calcium channel subunit alpha Cav1.1; Voltage-dependent L-type calcium channel subunit alpha-1S; Voltage-gated calcium channel subunit alpha Cav1.1
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