Rabbit anti-Human CASP8AP2 Polyclonal Antibody

Uniprot Id

Q9UKL3

Target Species

Human

Target Name

CASP8AP2

Target Full Name

CASP8-associated protein 2

Target Function

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.

Target Subcellular Location

Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.

Target Synonyms

AA387232; C8AP2_HUMAN; CASP 8 associated protein 2; CASP8 associated protein 2; CASP8-associated protein 2; CASP8AP2; Caspase 8 associated protein 2; CED 4; CED4; D4Ertd659e; FLASH homolog; FLASH homolog RIP 25; FLASH homolog RIP25; FLICE associated huge; FLICE associated huge protein; FLICE-associated huge protein; FLJ11208; KIAA1315; mKIAA1315; OTTMUSP00000005125; RIP 25; RIP25; RP23-69G24.1

Target Background

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.