Rabbit anti-Human CDK16 Polyclonal Antibody

Uniprot Id

Q00536

Target Species

Human

Target Name

CDK16

Target Full Name

Cyclin-dependent kinase 16

Target Function

Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).

Target Subcellular Location

Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.

Target Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

Target Tissue Specificity

Detected in pancreas islets (at protein level). Detected in brain and pancreas.

Target Synonyms

Cdk16; CDK16_HUMAN; Cell division protein kinase 16; Cyclin-dependent kinase 16; PCTAIRE; PCTAIRE protein kinase 1; PCTAIRE-motif protein kinase 1; PCTAIRE1; PCTGAIRE; PCTK1; Serine/threonine-protein kinase PCTAIRE-1

Target Background

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.