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The antibody against CERS3 was raised in rabbit using the Recombinant Human Ceramide synthase 3 protein (59-134AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against CERS3 was raised in rabbit using the Recombinant Human Ceramide synthase 3 protein (59-134AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-05616A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CERS3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | HRP conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ceramide synthase 3 protein (59-134AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IU89 |
Uniprot Id
Q8IU89
Target Species
Human
Target Name
CERS3
Target Full Name
Ceramide synthase 3
Target Function
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.
Target Involvement
Ichthyosis, congenital, autosomal recessive 9 (ARCI9)
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Tissue Specificity
Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level).
Target Synonyms
CERS3; LASS3; Ceramide synthase 3; CerS3; Dihydroceramide synthase 3; LAG1 longevity assurance homolog 3; Sphingosine N-acyltransferase CERS3; Ultra-long-chain ceramide synthase CERS3; Very-long-chain ceramide synthase CERS3
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