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The antibody against CHP2 was raised in rabbit using the Synthesized peptide derived from internal of HumanCHP2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against CHP2 was raised in rabbit using the Synthesized peptide derived from internal of HumanCHP2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
$297.00
Western blot analysis of extracts from Jurkat cells, K562 cells and HT-29 cells, using CHP2 antibody.
| Cat.No | ADC-41398A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CHP2 |
| Target Synonyms | CHP2 antibody; HCA520Calcineurin B homologous protein 2 antibody; Hepatocellular carcinoma-associated antigen 520 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of HumanCHP2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O43745 |
Uniprot Id
O43745
Target Species
Human
Target Name
CHP2
Target Full Name
Calcineurin B homologous protein 2
Target Function
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Target Subcellular Location
Nucleus. Cytoplasm. Cell membrane.
Target Protein Families
Calcineurin regulatory subunit family, CHP subfamily
Target Tissue Specificity
Expressed in malignantly transformed cells but not detected in normal tissues.
Target Synonyms
CHP2; HCA520Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520
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