Rabbit anti-Human CLPP Polyclonal Antibody

Uniprot Id

Q16740

Target Species

Human

Target Name

CLPP

Target Full Name

ATP-dependent Clp protease proteolytic subunit, mitochondrial

Target Function

Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.

Target Involvement

Perrault syndrome 3 (PRLTS3)

Target Subcellular Location

Mitochondrion matrix.

Target Protein Families

Peptidase S14 family

Target Tissue Specificity

Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.

Target Synonyms

ATP dependent protease ClpAP (E coli) proteolytic subunit; ATP dependent protease ClpAP proteolytic subunit; ATP dependent protease ClpAP proteolytic subunit human; ATP dependent proteolytic subunit homolog (E coli); ATP dependent proteolytic subunit homolog; Caseinolytic peptidase ATP dependent proteolytic subunit homolog; Caseinolytic protease ATP dependent proteolytic subunit E coli; clpP; ClpP caseinolytic peptidase ATP dependent proteolytic subunit; ClpP caseinolytic peptidase ATP dependent proteolytic subunit homolog; CLPP_HUMAN; Endopeptidase Clp; mitochondrial; Putative ATP dependent Clp protease proteolytic subunit mitochondrial; Putative ATP dependent Clp protease proteolytic subunit; Putative ATP-dependent Clp protease proteolytic subunit

Target Background

The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane.