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The antibody against CNBP was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 70-170 of human CNBP (NP_001120668.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against CNBP was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 70-170 of human CNBP (NP_001120668.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-10140A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CNBP |
| Target Synonyms | DM2; ZNF9; CNBP1; PROMM; RNF163; ZCCHC22; CNBP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, NIH/3T3, 293F | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 70-170 of human CNBP (NP_001120668.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | CGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA | Uniprot ID | P62633 |
Uniprot Id
P62633
Target Species
Human
Target Name
CNBP
Target Full Name
CCHC-type zinc finger nucleic acid binding protein
Target Function
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner.; Binds G-rich elements in target mRNA coding sequences. Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs.; Binds to RNA.; Binds to RNA.; Binds to RNA.; Binds to RNA.; Binds to RNA.
Target Involvement
Dystrophia myotonica 2 (DM2)
Target Subcellular Location
Nucleus. Cytoplasm. Endoplasmic reticulum.; [Isoform 1]: Cytoplasm.; [Isoform 2]: Cytoplasm.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.; [Isoform 8]: Cytoplasm.
Target Tissue Specificity
Expressed in the liver, kidney, spleen, testis, lung, muscle and adrenal glands.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
CCHC type zinc finger nucleic acid binding protein; Cellular nucleic acid binding protein; Cellular nucleic acid-binding protein; CNBP; CNBP_HUMAN; CNBP1; DM2; Erythroid differentiation related; PROMM; Proximal myotonic myopathy nucleic acid binding protein; RNF163; Sterol regulatory element binding protein; ZCCHC22; Zinc finger protein 273; Zinc finger protein 9 (a cellular retroviral nucleic acid binding protein); Zinc finger protein 9; ZNF9
Target Background
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
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