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The antibody against CREM was raised in rabbit using the Recombinant Human cAMP-responsive element modulator protein (145-321AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against CREM was raised in rabbit using the Recombinant Human cAMP-responsive element modulator protein (145-321AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-08044A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CREM |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human cAMP-responsive element modulator protein (145-321AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q03060 |
Uniprot Id
Q03060
Target Species
Human
Target Name
CREM
Target Full Name
cAMP-responsive element modulator
Target Function
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.; May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Target Subcellular Location
Nucleus.; [Isoform 6]: Cytoplasm. Nucleus.
Target Protein Families
BZIP family
Target Tissue Specificity
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Target Synonyms
ICER; CREM-2; hCREM-2; CREM
Target Background
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
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