Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against CUBN was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human Cubilin. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against CUBN was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human Cubilin. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
$167.00
| Cat.No | ADC-33704A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CUBN |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the N-terminal region of Human Cubilin. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O60494 |
Uniprot Id
O60494
Target Species
Human
Target Name
CUBN
Target Full Name
Cubilin
Target Function
Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
Target Involvement
Recessive hereditary megaloblastic anemia 1 (RH-MGA1)
Target Subcellular Location
Apical cell membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, coated pit. Endosome. Lysosome membrane; Peripheral membrane protein.
Target Tissue Specificity
Detected in kidney cortex (at protein level). Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
Target Synonyms
460 kDa receptor; cubilin (intrinsic factor-cobalamin receptor) ; Cubilin; Cubilin precursor ; Cubn; CUBN_HUMAN; IFCR; Intestinal intrinsic factor receptor; intrinsic factor B12-receptor; Intrinsic factor-cobalamin receptor; Intrinsic factor-vitamin B12 receptor; megaloblastic anemia 1; MGA1
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
