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The antibody against CYP2C18/CYP2C8/CYP2C9/CYP2C19 was raised in rabbit using the Synthesized peptide derived from internal of Human Cytochrome P450 2C8/9/18/19. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against CYP2C18/CYP2C8/CYP2C9/CYP2C19 was raised in rabbit using the Synthesized peptide derived from internal of Human Cytochrome P450 2C8/9/18/19. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
$297.00
Western blot analysis of extracts from LOVO cells, using Cytochrome P450 2C8/9/18/19 antibody.
| Cat.No | ADC-41652A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CYP2C18/CYP2C8/CYP2C9/CYP2C19 |
| Target Synonyms | CYP2C18Cytochrome P450 2C18 antibody; EC 1.14.14.1 antibody; CYPIIC18 antibody; Cytochrome P450-6b/29c antibody | Form | Liquid |
| Species Reactivity | Human | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human Cytochrome P450 2C8/9/18/19. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P33260 |
Uniprot Id
P33260
Target Species
Human
Target Name
CYP2C18
Target Full Name
Cytochrome P450 2C18
Target Function
A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Target Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Target Protein Families
Cytochrome P450 family
Target Synonyms
CYP2C18Cytochrome P450 2C18; EC 1.14.14.1; CYPIIC18; Cytochrome P450-6b/29c
Target Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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