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The antibody against CYP2C19 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CYP2C19. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
The antibody against CYP2C19 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CYP2C19. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
$167.00
Western Blot analysis of MOUSE-BRAIN cells using CYP2C19 Polyclonal Antibody
Western Blot analysis of HELA 293T cells using CYP2C19 Polyclonal Antibody2
| Cat.No | ADC-38905A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CYP2C19 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human CYP2C19. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P33261 |
Uniprot Id
P33261
Target Species
Human
Target Name
CYP2C19
Target Full Name
Cytochrome P450 2C19
Target Function
A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position. Catalyzes the epoxidation of double bonds of PUFA. Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol. Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position.
Target Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Target Protein Families
Cytochrome P450 family
Target Research Area
Others
Target Synonyms
(R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CP2CJ_HUMAN; CPCJ; CYP2C; CYP2C19; CYPIIC17; CYPIIC19; Cytochrome P-450 II C; Cytochrome P450 2C19; Cytochrome P450; subfamily IIC (mephenytoin 4-hydroxylase); polypeptide 19; Cytochrome P450-11A; Cytochrome P450-254C; Flavoprotein-linked monooxygenase; Mephenytoin 4 hydroxylase; Mephenytoin 4-hydroxylase; Microsomal monooxygenase; P450-11A; P45011A; P450C2C; S-mephenytoin 4-hydroxylase; Xenobiotic monooxygenase
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