Rabbit anti-Human CYTH4 Polyclonal Antibody

Uniprot Id

Q9UIA0

Target Species

Human

Target Name

CYTH4

Target Full Name

Cytohesin-4

Target Function

Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Target Subcellular Location

Cell membrane; Peripheral membrane protein.

Target Tissue Specificity

Expressed predominantly in peripheral blood leukocytes.

Target Synonyms

AI467541; CYH4_HUMAN; CYT4; Cyth4; Cytohesin 4; Cytohesin-4; DJ63G5.1; FLJ00017; PH; PH, SEC7 and coiled coil domain containing protein 4; Pleckstrin homology, SEC7, AND coiled coil domains protein 4; Pscd4; RGD1564842; SEC7 and coiled-coil domain-containing protein 4

Target Background

This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene.