Rabbit anti-Human DNAJC15 Polyclonal Antibody

Uniprot Id

Q9Y5T4

Target Species

Human

Target Name

DNAJC15

Target Full Name

DnaJ homolog subfamily C member 15

Target Function

Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP. Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.

Target Involvement

Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.

Target Subcellular Location

Mitochondrion inner membrane; Single-pass membrane protein.

Target Tissue Specificity

Expressed at highest levels in heart, followed by liver and kidney.

Target Synonyms

MCJ; HSD18; DNAJD1; DNAJC15

Target Background

Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of PAM complex, Tim23 associated import motor.