Rabbit anti-Human DPP9 Polyclonal Antibody

Uniprot Id

Q86TI2

Target Species

Human

Target Name

DPP9

Target Full Name

Dipeptidyl peptidase 9

Target Function

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism.

Target Subcellular Location

[Isoform 1]: Cytoplasm, cytosol.; [Isoform 2]: Nucleus.

Target Protein Families

Peptidase S9B family, DPPIV subfamily

Target Tissue Specificity

Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain.

Target Research Area

Metabolism

Target Synonyms

Dipeptidyl peptidase 9; Dipeptidyl peptidase IV related protein 2; Dipeptidyl peptidase IV-related protein 2; Dipeptidyl peptidase IX; Dipeptidyl peptidase like protein 9; Dipeptidyl peptidase-like protein 9; Dipeptidylpeptidase 9; Dipeptidylpeptidase IX; DKFZp762F117; DP 9; DP9; DPLP 9; DPLP9; DPP 9; DPP IX; DPP9; DPP9_HUMAN; DPRP 2; DPRP-2; DPRP2; FLJ16073

Target Background

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized.