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The antibody against DUX4 was raised in rabbit using the Recombinant Human Double homeobox protein 4 protein (217-402AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against DUX4 was raised in rabbit using the Recombinant Human Double homeobox protein 4 protein (217-402AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using DUX4 Antibody at dilution of 1: 100
Western Blot | Positive WB detected in: Hela whole cell lysate, PC-3 whole cell lysate, A549 whole cell lysate, HepG2 whole cell lysate | All lanes: DUX4 antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 45 kDa | Observed band size: 45 kDa2
| Cat.No | ADC-09968A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DUX4 |
| Target Synonyms | DUX4 antibody; DUX10Double homeobox protein 4 antibody; Double homeobox protein 10 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Double homeobox protein 4 protein (217-402AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UBX2 |
Uniprot Id
Q9UBX2
Target Species
Human
Target Name
DUX4
Target Full Name
Double homeobox protein 4
Target Function
Transcription factor that is selectively and transiently expressed in cleavage-stage embryos. Binds to double-stranded DNA elements with the consensus sequence 5'-TAATCTAATCA-3'. Binds to chromatin containing histone H3 acetylated at 'Lys-27' (H3K27ac) and promotes deacetylation of H3K27ac. In parallel, binds to chromatin that lacks histone H3 acetylation at 'Lys-27' (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at 'Lys-27' at new sites. Involved in transcriptional regulation of numerous genes, primarily as transcriptional activator, but mediates also repression of a set of target genes. Promotes expression of ZSCAN4 and KDM4E, two proteins with essential roles during early embryogenesis. Heterologous expression in cultured embryonic stem cells mediates also transcription of HERVL retrotransposons and transcripts derived from ACRO1 and HSATII satellite repeats. May activate expression of PITX1. May regulate microRNA (miRNA) expression. Inappropriate expression can inhibit myogenesis and promote apoptosis.; Probably inactive as a transcriptional activator, due to the absence of the C-terminal region that is important for transcriptional activation. Can inhibit transcriptional activation mediated by isoform 1. Heterologous expression of isoform 2 has no deleterious effect on cell survival.
Target Involvement
Facioscapulohumeral muscular dystrophy 1 (FSHD1)
Target Subcellular Location
[Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.
Target Protein Families
Paired homeobox family
Target Tissue Specificity
Isoform 1: Does not seem to be expressed in normal muscle, but is detected in muscle of individuals with FSHD, and also in testis (at protein level). Isoform 1: Does not seem to be expressed in normal muscle, but in muscle of individuals with FSHD, where
Target Research Area
Stem Cells
Target Synonyms
DUX4; DUX10Double homeobox protein 4; Double homeobox protein 10
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