Rabbit anti-Human EIF4E2 Polyclonal Antibody

Uniprot Id

O60573

Target Species

Human

Target Name

EIF4E2

Target Full Name

Eukaryotic translation initiation factor 4E type 2

Target Function

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression.

Target Subcellular Location

Cytoplasm. Cytoplasm, P-body.

Target Protein Families

Eukaryotic initiation factor 4E family

Target Synonyms

4E LP; 4EHP; 4ELP; EIF 4E type 2; eIF-4E type 2; EIF4 E2; EIF4E 2; eIF4E family; member 2; EIF4E HOMOLOGOUS PROTEIN; EIF4E like cap binding protein; EIF4E like protein 4E LP; EIF4E like protein 4ELP ; eIF4E type 2; EIF4E type 3; eIF4E-like 3; eIF4E-like protein 4E-LP; EIF4E2; Eukaryotic translation initiation factor 4E family member 2; Eukaryotic translation initiation factor 4E homologous protein; Eukaryotic translation initiation factor 4E like 3; Eukaryotic translation initiation factor 4E member 2; Eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; IF 4e; IF4E; IF4E2_HUMAN; mRNA cap binding protein 4EHP; mRNA cap binding protein type 3; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 3

Target Background

Enables ubiquitin protein ligase binding activity. Involved in positive regulation of miRNA mediated inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. Part of mRNA cap binding activity complex.