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The antibody against ERAP2 was raised in rabbit using the Human ERAP2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against ERAP2 was raised in rabbit using the Human ERAP2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-48628A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ERAP2 |
| Target Synonyms | ERAP2 antibody; LRAPEndoplasmic reticulum aminopeptidase 2 antibody; EC 3.4.11.- antibody; Leukocyte-derived arginine aminopeptidase antibody; L-RAP antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human ERAP2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6P179 |
Uniprot Id
Q6P179
Target Species
Human
Target Name
ERAP2
Target Full Name
Endoplasmic reticulum aminopeptidase 2
Target Function
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Target Protein Families
Peptidase M1 family
Target Tissue Specificity
Ubiquitously expressed. Highly expressed in spleen and leukocytes.
Target Synonyms
ERAP2; LRAPEndoplasmic reticulum aminopeptidase 2; EC 3.4.11.-; Leukocyte-derived arginine aminopeptidase; L-RAP
Target Background
This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5.
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