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The antibody against ERCC4 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human ERCC4. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against ERCC4 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human ERCC4. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
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Western Blot analysis of 293 cells using ERCC4 Polyclonal Antibody
Western Blot analysis of Jurkat cells using ERCC4 Polyclonal Antibody2
| Cat.No | ADC-38718A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ERCC4 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human ERCC4. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q92889 |
Uniprot Id
Q92889
Target Species
Human
Target Name
ERCC4
Target Full Name
DNA repair endonuclease XPF
Target Function
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.
Target Involvement
Xeroderma pigmentosum complementation group F (XP-F); XFE progeroid syndrome (XFEPS); Xeroderma pigmentosum type F/Cockayne syndrome (XPF/CS); Fanconi anemia complementation group Q (FANCQ)
Target Subcellular Location
Nucleus.
Target Protein Families
XPF family
Target Synonyms
DNA excision repair protein ERCC 4; DNA excision repair protein ERCC-4; DNA excision repair protein ERCC4; DNA repair endonuclease XPF; DNA repair protein complementing XP F cells; DNA repair protein complementing XP-F cells; ERCC 11; ERCC 4; ERCC11; ERCC4; Excision repair complementing defective in Chinese hamster; Excision repair cross complementing rodent repair deficiency complementation group 4; excision repair cross-complementation group 4; FANCQ; RAD 1; RAD1; Xeroderma pigmentosum complementation group F; Xeroderma pigmentosum group F complementing protein; Xeroderma pigmentosum group F-complementing protein; Xeroderma pigmentosum VI; XP; group G; XP6; XPF_HUMAN
Target Background
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).
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