Rabbit anti-Human ESRRA Polyclonal Antibody

The antibody against ESRRA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-76 of human ESRRA (NP_004442.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-04499A

Number

Cat.No	ADA-04499A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ESRRA
Target Synonyms	ERR1; ERRa; ESRL1; NR3B1; ERRalpha; ESRRA	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	BT-474, HT-29, MCF7, SW620	Application	ELISA, WB, IF/ICC

Cat.No

ADA-04499A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ESRRA

Target Synonyms

ERR1; ERRa; ESRL1; NR3B1; ERRalpha; ESRRA

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

BT-474, HT-29, MCF7, SW620

Application

ELISA, WB, IF/ICC

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-76 of human ESRRA (NP_004442.3).	Target Species	Human
Immunogen Sequence	MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPK	Uniprot ID	P11474

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-76 of human ESRRA (NP_004442.3).

Target Species

Human

Immunogen Sequence

MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPK

Uniprot ID

P11474

Background Information

Uniprot Id

P11474
Target Species

Human
Target Name

ESRRA
Target Full Name

Steroid hormone receptor ERR1
Target Function

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Target Subcellular Location

Nucleus. Cytoplasm.
Target Protein Families

Nuclear hormone receptor family, NR3 subfamily
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

Err 1; ERR a; ERR alpha; ERR-alpha; Err1; ERR1 protein; ERR1_HUMAN; ERRa; ERRalpha; ESRL 1; ESRL1; ESRR A; Esrra; Estrogen receptor like 1; Estrogen receptor related 1; estrogen receptor related receptor alpha; Estrogen receptor-like 1; Estrogen related receptor alpha; Estrogen-related receptor alpha; Estrra; hERR1; NR3B1; Nuclear receptor subfamily 3 group B member 1; Steroid hormone receptor ERR1
Target Background

The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1.

Rabbit anti-Human ESRRA Polyclonal Antibody

Specifications

Immunogen Information

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