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The antibody against GDF10 was raised in rabbit using the Recombinant Human Growth/differentiation factor 10 protein (369-478AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against GDF10 was raised in rabbit using the Recombinant Human Growth/differentiation factor 10 protein (369-478AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-07985A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GDF10 |
| Form | Liquid | Species Reactivity | Human, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Growth/differentiation factor 10 protein (369-478AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P55107 |
Uniprot Id
P55107
Target Species
Human
Target Name
GDF10
Target Full Name
Growth/differentiation factor 10
Target Function
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family
Target Tissue Specificity
Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
Target Research Area
Cancer
Target Synonyms
BIP; BMP 3b; BMP-3b; BMP3B; BMP3B_HUMAN; Bone inducing protein; Bone morphogenetic protein 3b [Precursor]; Bone morphogenetic protein 3b; Bone-inducing protein; GDF 10; GDF-10; Gdf10; growth differentiation factor 10; Growth/differentiation factor 10
Target Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer.
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