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The antibody against GFRAL was raised in rabbit using the Recombinant Human GDNF family receptor alpha-like protein (19-351AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on WB.
The antibody against GFRAL was raised in rabbit using the Recombinant Human GDNF family receptor alpha-like protein (19-351AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on WB.
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Western BlotPositive WB detected in:Mouse Liver tissue lysateAll lanes: GFRAL antibody at 1:1000SecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 45 kDaObserved band size: 55 kDa
| Cat.No | ADC-19694A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GFRAL |
| Target Synonyms | bA360D14.1 antibody; C6orf144 antibody; GDNF family receptor alpha-like antibody; Gfral antibody; GFRAL_HUMAN antibody; GRAL antibody; IVFI9356 antibody; UNQ9356 antibody; UNQ9356/PRO34128 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human GDNF family receptor alpha-like protein (19-351AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6UXV0 |
Uniprot Id
Q6UXV0
Target Species
Human
Target Name
GFRAL
Target Full Name
GDNF family receptor alpha-like
Target Function
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Target Subcellular Location
Cell membrane; Single-pass membrane protein; Extracellular side.
Target Protein Families
GDNFR family
Target Tissue Specificity
Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level). Detected at low levels in testis and adipose tissue.
Target Research Area
Cell Biology
Target Synonyms
bA360D14.1; C6orf144; GDNF family receptor alpha-like; Gfral; GFRAL_HUMAN; GRAL; IVFI9356; UNQ9356; UNQ9356/PRO34128
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