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The antibody against GGCT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human GGCT (NP_076956.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GGCT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human GGCT (NP_076956.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03873A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GGCT |
| Target Synonyms | GGC; GCTG; CRF21; C7orf24; GGCT | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, A-431, A-549 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human GGCT (NP_076956.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKKGETQTL | Uniprot ID | O75223 |
Uniprot Id
O75223
Target Species
Human
Target Name
GGCT
Target Full Name
Gamma-glutamylcyclotransferase
Target Function
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
Target Protein Families
Gamma-glutamylcyclotransferase family
Target Research Area
Metabolism
Target Synonyms
C7orf24; CRF21; Cytochrome c-releasing factor 21; Gamma glutamyl cyclotransferase; Gamma-glutamylcyclotransferase; GCTG; GGC; Ggct; GGCT_HUMAN
Target Background
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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