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The antibody against GLIS2 was raised in rabbit using the Recombinant Human Zinc finger protein GLIS2 protein (332-505AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against GLIS2 was raised in rabbit using the Recombinant Human Zinc finger protein GLIS2 protein (332-505AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-03180A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GLIS2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Zinc finger protein GLIS2 protein (332-505AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BZE0 |
Uniprot Id
Q9BZE0
Target Species
Human
Target Name
GLIS2
Target Full Name
Zinc finger protein GLIS2
Target Function
Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation.
Target Involvement
Nephronophthisis 7 (NPHP7)
Target Subcellular Location
Nucleus speckle. Cytoplasm.
Target Protein Families
GLI C2H2-type zinc-finger protein family
Target Tissue Specificity
Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.
Target Synonyms
FLJ38247; GLI similar 2; GLI-similar 2; GLIS 2; GLIS family zinc finger 2; glis2; GLIS2_HUMAN; Kruppel like zinc finger protein GLIS2; Neuronal Krueppel-like protein; Zinc finger protein GLIS2
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