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The antibody against GNA12 was raised in rabbit using the Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against GNA12 was raised in rabbit using the Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-05170A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GNA12 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Biotin conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q03113 |
Uniprot Id
Q03113
Target Species
Human
Target Name
GNA12
Target Full Name
Guanine nucleotide-binding protein subunit alpha-12
Target Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.
Target Subcellular Location
Cell membrane; Lipid-anchor. Lateral cell membrane; Lipid-anchor. Cytoplasm.
Target Protein Families
G-alpha family, G(12) subfamily
Target Synonyms
RMP; gep; NNX3; HG1M1; GNA12
Target Background
Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in regulation of TOR signaling and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in focal adhesion.
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