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The antibody against GNAO1 was raised in rabbit using the Recombinant Human Guanine nucleotide-binding protein G(o) subunit alpha protein (60-180AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against GNAO1 was raised in rabbit using the Recombinant Human Guanine nucleotide-binding protein G(o) subunit alpha protein (60-180AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human brain tissue using GNAO1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using GNAO1 Antibody at dilution of 1:1002
| Cat.No | ADC-16889A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GNAO1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Guanine nucleotide-binding protein G(o) subunit alpha protein (60-180AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P09471 |
Uniprot Id
P09471
Target Species
Human
Target Name
GNAO1
Target Full Name
Guanine nucleotide-binding protein G(o) subunit alpha
Target Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.
Target Involvement
Epileptic encephalopathy, early infantile, 17 (EIEE17); Neurodevelopmental disorder with involuntary movements (NEDIM)
Target Subcellular Location
Cell membrane. Membrane; Lipid-anchor.
Target Protein Families
G-alpha family, G(i/o/t/z) subfamily
Target Synonyms
DKFZp686O0962; G alpha o; G protein alpha 0; Galphao; GNAO 1; GNAO; GNAO_HUMAN; GNAO1; Go alpha; Guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O; Guanine nucleotide binding protein alpha activating polypeptide ; Guanine nucleotide binding protein G(o) subunit alpha; Guanine nucleotide-binding protein G(o) subunit alpha
Target Background
The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene.
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