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The antibody against GNL3 was raised in rabbit using the Recombinant Human Guanine nucleotide-binding protein-like 3 protein (1-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against GNL3 was raised in rabbit using the Recombinant Human Guanine nucleotide-binding protein-like 3 protein (1-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human liver tissue using GNL3 Antibody at dilution of 1:100
| Cat.No | ADC-44121A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GNL3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Guanine nucleotide-binding protein-like 3 protein (1-240AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BVP2 |
Uniprot Id
Q9BVP2
Target Species
Human
Target Name
GNL3
Target Full Name
Guanine nucleotide-binding protein-like 3
Target Function
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation.
Target Subcellular Location
Nucleus. Nucleus, nucleolus.
Target Protein Families
TRAFAC class YlqF/YawG GTPase family
Target Tissue Specificity
Increased levels in lung tissue in cancer patients.
Target Synonyms
C77032 ; E2 induced gene 3 protein; E2-induced gene 3 protein; E2IG3; Estradiol induced nucleotide binding protein; GNL3; GNL3_HUMAN; Guanine nucleotide binding protein like 3 (nucleolar); Guanine nucleotide binding protein like 3; Guanine nucleotide-binding protein-like 3; MGC800; NNP47; Novel nucleolar protein 47; NS; Nucleolar GTP binding protein 3 ; Nucleolar GTP-binding protein 3; Nucleostemin; Putative nucleotide binding protein estradiol induced
Target Background
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.
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