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The antibody against GRAMD1B was raised in rabbit using the Recombinant Human GRAM domain-containing protein 1B protein (235-504AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against GRAMD1B was raised in rabbit using the Recombinant Human GRAM domain-containing protein 1B protein (235-504AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human gastric cancer using GRAMD1B Antibody at dilution of 1:100
Immunofluorescent analysis of A549 cells using GRAMD1B Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-20133A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GRAMD1B |
| Target Synonyms | GRAMD1B; KIAA1201; UNQ3032/PRO9834; Protein Aster-B; GRAM domain-containing protein 1B | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human GRAM domain-containing protein 1B protein (235-504AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q3KR37 |
Uniprot Id
Q3KR37
Target Species
Human
Target Name
GRAMD1B
Target Full Name
Protein Aster-B
Target Function
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain. At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER.
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
Target Synonyms
GRAMD1B; KIAA1201; UNQ3032/PRO9834; Protein Aster-B; GRAM domain-containing protein 1B
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