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The antibody against GRK1 was raised in rabbit using the Synthetic peptide of Human GRK1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against GRK1 was raised in rabbit using the Synthetic peptide of Human GRK1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-28344A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GRK1 |
| Target Synonyms | EC=2.7.11.14 antibody; G protein-coupled receptor kinase 1 antibody; GPRK1 antibody; Grk1 antibody; Rhodopsin kinase antibody; RHOK antibody; RK antibody; RK_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human GRK1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15835 |
Uniprot Id
Q15835
Target Species
Human
Target Name
GRK1
Target Full Name
Rhodopsin kinase GRK1
Target Function
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. May play a role in the maintenance of the outer nuclear layer in the retina.
Target Involvement
Night blindness, congenital stationary, Oguchi type 2 (CSNBO2)
Target Subcellular Location
Membrane; Lipid-anchor. Cell projection, cilium, photoreceptor outer segment.
Target Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
Target Tissue Specificity
Retinal-specific. Expressed in rods and cones cells.
Target Synonyms
EC=2.7.11.14; G protein-coupled receptor kinase 1; GPRK1; Grk1; Rhodopsin kinase; RHOK; RK; RK_HUMAN
Target Background
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2).
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