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The antibody against HBP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human HBP1 (NP_036389.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HBP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human HBP1 (NP_036389.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00629A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HBP1 |
| Target Synonyms | HBP1 | Form | Liquid |
| Species Reactivity | Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human HBP1 (NP_036389.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O60381 | Immunogen Sequence |
Uniprot Id
O60381
Target Species
Human
Target Name
HBP1
Target Full Name
HMG box-containing protein 1
Target Function
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Target Subcellular Location
Nucleus.
Target Synonyms
FLJ16340; HBP 1; HBP1; HBP1_HUMAN; High mobility group box transcription factor 1; HMG box containing protein 1; HMG box transcription factor 1; HMG box-containing protein 1
Target Background
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of lipid transport; negative regulation of reactive oxygen species biosynthetic process; and negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Biomarker of osteoarthritis.
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